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Can dietary magnesium modulate lipoprotein metabolism?
R B Singh1, S S Rastogi, V K Sharma
1Medical Hospital and Research Center, Moradabad, India.
Magnesium and Trace Elements
|January 1, 1990
Summary
A magnesium-rich diet significantly reduced total cholesterol, LDL cholesterol, and triglycerides over 12 weeks. This dietary intervention also showed a positive impact on HDL cholesterol, particularly in individuals with low magnesium levels.
Area of Science:
- Cardiovascular Health
- Nutritional Science
- Biochemistry
Background:
- Dyslipidemia is a significant risk factor for cardiovascular disease.
- Dietary interventions are crucial for managing lipid profiles.
- The role of magnesium in lipid metabolism requires further elucidation.
Purpose of the Study:
- To investigate the effect of a magnesium-rich diet on serum lipid levels.
- To compare lipid profile changes between a magnesium-rich diet and a usual diet.
- To assess magnesium's impact on high-density-lipoprotein (HDL) cholesterol.
Main Methods:
- A randomized, single-blinded, controlled study involving 430 participants (aged 25-63 years).
- Intervention group received a magnesium-rich diet (1,142 mg/day) for 12 weeks.
- Control group received a usual diet (438 mg/day) for 12 weeks.
Main Results:
- The magnesium-rich diet group showed significant reductions in total cholesterol (10.7%), LDL cholesterol (10.5%), and triglycerides (10.1%).
- HDL cholesterol increased by 2.0 mg/dl in the magnesium group, while decreasing marginally in the control group.
- Hypomagnesemic patients in the intervention group experienced a 10.9% increase in HDL cholesterol.
Conclusions:
- Dietary magnesium may contribute to reducing total cholesterol, LDL cholesterol, and triglycerides.
- Magnesium supplementation may play a role in maintaining or increasing HDL cholesterol levels.
- Further research with longer follow-up is needed to confirm magnesium's role in lipid management.