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Na(+)-dependent Mg2+ efflux from Mg(2+)-loaded rat thymocytes and HL 60 cells
1Institute of Molecular Biology and Biochemistry, Free University of Berlin, FRG.
Magnesium and Trace Elements
|January 1, 1990
Abstract:
Mg(2+)-loaded rat thymocytes and HL 60 (human promyelocytic leukemia) cells expressed a high rate of Na(+)-dependent net Mg2+ efflux which was inhibited by two thirds by 1 mM amiloride. During net Mg2+ efflux, extracellular Na+ was taken up at a stoichiometric ratio of 2 Na+ to 1 Mg2+, indicating electroneutral Na+/Mg2+ antiport as found for erythrocytes. Na(+)-independent Mg2+ efflux was not significantly expressed in these cell types.