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Additional results for 'Sequential design approaches for bioequivalence studies with crossover designs'

Timothy H Montague1, Diane Potvin, Charles E Diliberti

  • 1GlaxoSmithKline, Inc., King of Prussia, PA, USA.

Pharmaceutical Statistics
|February 11, 2011
PubMed
Summary

This study evaluates two-stage crossover bioequivalence (BE) designs for sample size reestimation. Method D is recommended when assuming a geometric mean ratio (GMR) of 0.90 to maintain acceptable Type I error rates.

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