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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jun 4, 2026

Analysis of Craniomaxillofacial Malformations in Mice Using Three-dimensional Microcomputed Tomography

Analysis of Craniomaxillofacial Malformations in Mice Using Three-dimensional Microcomputed Tomography

Published on: January 17, 2025

Mouse resources for craniofacial research.

Stephen A Murray¹

¹The Jackson Laboratory, Bar Harbor, Maine, USA. steve.murray@jax.org

Genesis (New York, N.Y. : 2000)

|February 11, 2011

Summary

This summary is machine-generated.

Mice are vital for studying craniofacial development and disorders. New large-scale initiatives are creating essential mouse models and tools to advance research on complex craniofacial conditions.

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Last Updated: Jun 4, 2026

Analysis of Craniomaxillofacial Malformations in Mice Using Three-dimensional Microcomputed Tomography

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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Area of Science:

Developmental Biology
Genetics
Craniofacial Research

Background:

Mice are crucial model organisms for understanding craniofacial development and dysmorphology.
Existing genetic mouse strains and tools for craniofacial research are not always publicly available.

Purpose of the Study:

To review current mouse resources for craniofacial research.
To discuss large-scale initiatives and future directions for generating and accessing essential mouse models.

Main Methods:

Review of existing literature and ongoing large-scale international initiatives.
Analysis of the role of genetically defined mouse strains in dissecting craniofacial development.

Main Results:

Numerous gene knockout and Cre driver strains exist but are often not in public repositories.
Large-scale efforts are underway to create comprehensive sets of targeted mutations and new Cre driver strains.
Genetically defined panels of mouse strains aid in studying the multigenic nature of craniofacial development.

Conclusions:

Improved access to and awareness of mouse resources are critical for advancing craniofacial research.
Future directions involve continued development of mouse models and collaborative resource generation.