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Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
The vitreomacular interface in retinal vein occlusion
Thomas Bertelmann1, Nadia Kičová, Anke Messerschmidt-Roth
1Department of Ophthalmology, Philipps University Marburg, Marburg, Germany. thomas.bertelmann@staff.uni-marburg.de
Acta Ophthalmologica
|February 12, 2011
Summary
Patients with retinal vein occlusion, specifically central (CRVO) or branch (BRVO), show a higher rate of posterior vitreous cortex attachment. This contrasts with healthy individuals, indicating a potential link between vein occlusion and vitreous adhesion.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Vitreoretinal Interface
Background:
- Retinal vein occlusions (RVOs) are a significant cause of vision loss.
- Posterior vitreous detachment (PVD) is a common age-related change.
- The relationship between RVOs and PVD status requires further investigation.
Purpose of the Study:
- To assess posterior vitreous adhesion in patients with a history of central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO).
- To compare PVD status in RVO patients with healthy age-matched controls.
Main Methods:
- Retrospective chart review of 132 patients (133 eyes) with CRVO or BRVO history.
- Vitreous adhesion status (attached, partially detached, completely detached) determined during vitrectomy.
- Comparison with natural PVD time-course data from healthy controls.
Main Results:
- Eighty-one eyes met inclusion criteria; 52 with CRVO, 29 with BRVO.
- In CRVO patients, 90% had attached posterior vitreous; in BRVO, 93% had attached.
- RVO patients, particularly those aged 70-79, showed significantly higher posterior vitreous attachment rates compared to healthy controls.
Conclusions:
- The posterior vitreous cortex remains attached more frequently in patients with a history of CRVO or BRVO across all age groups.
- This suggests a potential impact of retinal vein occlusion on the natural progression of posterior vitreous detachment.
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