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Updated: Jun 4, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Use of non-partitioned ventilator tubing results in dead-space ventilation hypercarbia
Bassem O Asaad1, Mohammad Helwani, David M Wheeler
1Department of Anesthesiology, Stony Brook University, Stony Brook, NY, USA.
Abstract:
We present a case of severe postoperative hypercarbia in a patient with severe COPD. Hypercarbia and respiratory acidosis continued to increase despite maximal ventilation, bronchodilator therapy, sedation, and paralysis. Mistaken use of non-partitioned ventilator circuit was the cause of the hypercarbia. The ventilator's self-test function failed to detect the error. We changed to a partitioned-lumen circuit, with much less ventilation dead space, and the hypercarbia resolved immediately.
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