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Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
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Related Experiment Video

Updated: Jun 4, 2026

Preparation of Myeloid Derived Suppressor Cells (MDSC) from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting (AutoMACS)

Preparation of Myeloid Derived Suppressor Cells (MDSC) from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting (AutoMACS)

Published on: June 18, 2012

MDSC in autoimmunity.

James G Cripps¹, James D Gorham

¹Department of Microbiology & Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA.

International Immunopharmacology

|February 12, 2011

Summary

This summary is machine-generated.

Myeloid-derived suppressor cells (MDSC) show promise in treating autoimmune diseases. Dysfunctional MDSC may contribute to autoimmune disease pathogenesis by failing to control T cell responses.

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Area of Science:

Immunology
Autoimmunity
Cellular Biology

Background:

Myeloid-derived suppressor cells (MDSC) were first identified nearly two decades ago.
Historically, MDSC research focused on cancer models and patients, where they inhibit anti-tumor immunity.
Recent studies increasingly report MDSC-like populations in animal models of autoimmune diseases.

Purpose of the Study:

To explore the role of MDSC in autoimmune diseases.
To investigate the potential of MDSC to suppress autoimmune responses and limit tissue damage.
To test the hypothesis that impaired endogenous MDSC function contributes to autoimmune disease development.

Main Methods:

Review of existing literature on MDSC in cancer and autoimmune disease models.
Analysis of studies reporting MDSC-like cell populations in autoimmune settings.
Comparative analysis of MDSC functions in cancer versus autoimmunity.

Main Results:

MDSC populations with immunosuppressive properties are increasingly recognized in autoimmune disease models.
Unlike their role in cancer, MDSC in autoimmunity may suppress pathogenic immune responses.
Evidence suggests MDSC can limit autoimmune-driven tissue injury.

Conclusions:

MDSC represent a potential therapeutic target for autoimmune diseases.
The immunosuppressive function of MDSC is crucial for maintaining immune homeostasis.
Failure of endogenous MDSC to regulate T cell responses may drive autoimmune pathogenesis.