Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Signaling Feedback Loops01:07

Cell Signaling Feedback Loops

Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1-5 and Therapeutic Implications in Neuroendocrine and Non-Neuroendocrine Malignancies.

International journal of cancer·2026
Same author

Corrigendum to "Metabolic plasticity and optimal redox homeostasis are essential for efficient metastatic colonization" [Mol Metab 109 (2026) 102382/42155637].

Molecular metabolism·2026
Same author

A retrospective study of CKDu progression in Sri Lanka: analysis of kidney biopsies and association with risk factors.

BMC nephrology·2026
Same author

RepurNet: A network medicine framework for systematic drug repurposing and disease vulnerability discovery.

iScience·2026
Same author

Novel CAR T cell blend targeting PDPN and GD2 to overcome glioblastoma heterogeneity.

Journal for immunotherapy of cancer·2026
Same author

Metabolic plasticity and optimal redox homeostasis are essential for efficient metastatic colonization.

Molecular metabolism·2026
Same journal

Causal intervention validation of gene regulatory signals in scGPT.

Journal of biomedical informatics·2026
Same journal

CoAff-DTI: Fine-grained drug-target interaction prediction using pre-trained language models and affinity-guided mechanisms.

Journal of biomedical informatics·2026
Same journal

Evaluation of temporal preservation in synthetic longitudinal patient data.

Journal of biomedical informatics·2026
Same journal

ARKE: An ontology-driven framework for automated mapping of local radiology procedure terms to the LOINC-RadLex playbook using large language model.

Journal of biomedical informatics·2026
Same journal

A validation-driven training controller for cross-lingual biomedical NER via reinforcement learning-based adaptive loss weighting.

Journal of biomedical informatics·2026
Same journal

ASP-HR: An Adaptive Spatial Perception and Hierarchical Reasoning mechanism for document-level biomedical relation extraction.

Journal of biomedical informatics·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Inferring cell cycle feedback regulation from gene expression data.

Fulvia Ferrazzi1, Felix B Engel, Erxi Wu

  • 1Dipartimento di Informatica e Sistemistica, Università degli Studi di Pavia, Pavia, Italy. fulvia.ferrazzi@unipv.it

Journal of Biomedical Informatics
|February 12, 2011
PubMed
Summary
This summary is machine-generated.

Researchers identified a 10-gene feedback loop crucial for cell cycle regulation using a dynamic Bayesian network. This approach highlights key genes for biological process dynamics and potential therapeutic targets.

More Related Videos

Analysis of Cell Cycle Position in Mammalian Cells
12:19

Analysis of Cell Cycle Position in Mammalian Cells

Published on: January 21, 2012

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

Related Experiment Videos

Last Updated: Jun 4, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Analysis of Cell Cycle Position in Mammalian Cells
12:19

Analysis of Cell Cycle Position in Mammalian Cells

Published on: January 21, 2012

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

Area of Science:

  • Systems biology
  • Genomics
  • Molecular biology

Background:

  • Feedback control mechanisms are vital for biological system robustness against disturbances.
  • Genes within feedback structures play critical roles in regulating cellular processes.

Purpose of the Study:

  • To identify feedback loops in cell cycle regulation using a dynamic Bayesian network approach.
  • To pinpoint critical genes influencing biological process dynamics.

Main Methods:

  • Analysis of transcriptional profiles of the cell cycle in HeLa cancer cells.
  • Application of a dynamic Bayesian network to identify gene feedback structures.
  • In silico analysis to assess the role of identified genes in system dynamics.

Main Results:

  • A feedback loop structure comprising 10 genes involved in cell cycle regulation was identified.
  • In silico analyses confirmed the significant roles of these genes in system dynamics.
  • Experimental validation supported the central role of 8 of the 10 identified genes in cell cycle regulation.

Conclusions:

  • A novel method for identifying critical genes in biological process dynamics was developed.
  • The identified feedback loop genes are crucial for cell cycle regulation.
  • This approach may aid in discovering therapeutic targets for diseases linked to disrupted biological dynamics.