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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Conjugated Proteins02:50

Conjugated Proteins

Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Vaccinations01:51

Vaccinations

Overview
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...

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Related Experiment Video

Updated: Jun 4, 2026

Expression and Purification of Virus-like Particles for Vaccination
06:17

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

Proteomics for development of vaccine.

Monika Adamczyk-Poplawska1, Sergiusz Markowicz, Elzbieta K Jagusztyn-Krynicka

  • 1Department of Virology, Institute of Microbiology, Biology Faculty, Warsaw University, Warsaw, Poland.

Journal of Proteomics
|February 12, 2011
PubMed
Summary

Genome and proteomics data accelerate the development of new vaccines and therapies against infectious diseases. This review highlights how proteomics advances antibacterial, antiviral, and anticancer vaccine construction.

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Area of Science:

  • Genomics and Proteomics
  • Vaccinology
  • Immunology

Background:

  • Genome projects provide extensive data on pathogenic species, fostering hopes for new vaccines and drugs.
  • Proteomics complements genomics, offering insights into pathogen-host interactions.
  • Immunomics and vaccinomics aid in identifying immunogenic proteins and understanding host responses.

Purpose of the Study:

  • To review the global status of vaccinology using WHO data.
  • To describe the impact of proteomic strategies on vaccine development.
  • To explore the application of proteomics in understanding disease mechanisms and prevention.

Main Methods:

  • Review of global vaccinology data.
  • Analysis of proteomic strategies in vaccine development.
  • Investigation of disease mechanisms and prevention through proteomics.

Main Results:

  • Proteomics accelerates the identification and characterization of vaccine candidate antigens.
  • Proteomic strategies have significantly advanced the construction of antibacterial, antiviral, and anticancer vaccines.
  • Proteomics provides valuable information on pathogen-host cell interactions.

Conclusions:

  • Proteomics is a powerful tool for developing novel vaccines and therapeutic drugs.
  • Integrating proteomics with genomics, immunomics, and vaccinomics enhances pathogen research.
  • Proteomic approaches are crucial for combating infectious diseases and developing cancer vaccines.