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Functional imaging of sleep vertex sharp transients.

John M Stern1, Matteo Caporro, Zulfi Haneef

  • 1Department of Neurology, University of California, Los Angeles, United States. jstern@ucla.edu

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|February 12, 2011
PubMed
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Vertex sharp transients (VSTs), early non-REM sleep markers, are generated in primary sensorimotor brain regions. This functional MRI study reveals VSTs involve networks processing vision, hearing, and touch, suggesting a role in sleep sensory experiences.

Area of Science:

  • Neuroscience
  • Sleep Science
  • Neuroimaging

Background:

  • Vertex sharp transients (VSTs) are recognized electroencephalographic (EEG) discharges marking early non-REM sleep.
  • The precise origin and function of VSTs remain largely unelucidated in sleep physiology.
  • Investigating VST generation is crucial for understanding sleep mechanisms.

Purpose of the Study:

  • To investigate the cerebral origins and functional correlates of VSTs using simultaneous EEG and functional MRI (fMRI).
  • To identify brain regions associated with VST generation during drowsiness and light sleep.
  • To explore the potential role of VSTs in sensory processing during sleep.

Main Methods:

  • Simultaneous electroencephalography (EEG) and functional MRI (fMRI) were recorded from seven participants during drowsiness and light sleep.

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  • VST occurrences were modeled using an impulse function convolved with a hemodynamic response function to identify correlating brain regions.
  • Statistical analysis involved thresholding at Z>2.3 to determine significant signal changes.

    • Main Results:

    • Two hundred VSTs were identified across participants.
    • Significantly increased fMRI signal was observed bilaterally in medial central, lateral precentral, posterior superior temporal, and medial occipital cortex.
    • No regions of decreased signal were associated with VSTs.

    Conclusions:

    • The identified brain regions align with electrophysiological data from animal models and human sleep imaging studies.
    • The findings specifically implicate primary sensorimotor cortical regions involved in vision, hearing, and touch in VST generation.
    • The results suggest VSTs may play a role in sensory experience during sleep, forming a network with associated sensory processing regions.