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Published on: October 14, 2014
Anaphylactic reaction after methylene blue-treated plasma transfusion
P Dewachter1, S Castro, P Nicaise-Roland
1Assistance Publique Hôpitaux de Paris, Hôpital Necker-Enfants Malades, Service d'Anesthésie-Réanimation & SAMU de Paris, 149 Rue de Sèvres, Paris, France. pascale.dewachter@yahoo.fr
Abstract:
Methylene blue-treated fresh-frozen plasma (MB-FFP) is mainly used in Europe. The advantage of the methylene blue system is that units can be treated individually. The combined action of methylene blue and illumination is a photodynamic process preventing viral RNA and DNA replication. We report the first immediate allergic hypersensitivity reaction to methylene blue-treated plasma transfusion. The clinical course and subsequent assessment of the allergic reaction, including skin tests and basophil activation test, confirmed methylene blue-induced IgE-mediated anaphylaxis. All immediate reactions after MB-FFP transfusion should be investigated to document the underlying mechanism.
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Blood Transfusion
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...