Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Endoscopic Studies I: Bronchoscopy and Thoracoscopy

Endoscopic Studies I: Bronchoscopy and Thoracoscopy

Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due to...

Parenteral Anesthetics: Overview

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.

COPD: Management Using Bronchodilators and Corticosteroids

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...

Inhalational Anesthetics: Overview

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...

Endoscopic Studies II: Thoracocentesis

Endoscopic Studies II: Thoracocentesis

Thoracentesis(Thoracocentesis), commonly known as pleural tap, is a medical procedure where a 22 gauge needle is inserted into the pleural space, the area between the lung and chest wall. This procedure is commonly performed to diagnose or treat various respiratory disorders.
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...

General Anesthesia: Overview

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Central pseudorapidity gaps in events with a leading antiproton at the fermilab tevatron pp collider.

Physical review letters·2003

Same author

Search for the supersymmetric partner of the top quark in dilepton events from pp collisions at square root of s=1.8 TeV.

Physical review letters·2003

Same author

Search for associated production of Upsilon and vector boson in pp collisions at sqrt[s]=1.8 TeV.

Physical review letters·2003

Same author

[Conjunctival semi-lunar fold nevus of presumed late onset].

Journal francais d'ophtalmologie·2003

Same author

[Pseudotumoral eyelid inflammation. Apropos of an anatomo-clinical case].

Journal francais d'ophtalmologie·2003

Same author

Rapid testing for nitrate reductase activity of Mycobacterium tuberculosis grown in an automated culture system.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2003

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

Propofol versus propofol plus hydrocodone for flexible bronchoscopy: a randomised study.

L Schlatter¹, E Pflimlin, B Fehrke

¹Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital Basel, Basel, Switzerland.

The European Respiratory Journal

|February 12, 2011

Summary

This summary is machine-generated.

Combining propofol with hydrocodone significantly reduces cough during flexible bronchoscopy compared to propofol alone. This combination is safe and effective for improving patient comfort and procedure success.

Related Experiment Videos

Last Updated: Jun 4, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

Area of Science:

Anesthesiology
Pulmonology
Pharmacology

Background:

Flexible bronchoscopy often requires sedation, with propofol and benzodiazepine-opiate combinations being common.
The efficacy of propofol combined with an opiate versus propofol alone for cough suppression during bronchoscopy remains unclear.

Purpose of the Study:

To investigate if combining propofol with hydrocodone is superior to propofol alone for suppressing cough during flexible bronchoscopy.

Main Methods:

A double-blind, randomized study involving 300 patients undergoing flexible bronchoscopy.
Patients received either propofol with hydrocodone or propofol alone.
Cough score, assessed via a visual analogue scale by physicians, nurses, and patients, was the primary endpoint.

Main Results:

The propofol-hydrocodone group showed significantly lower median cough scores compared to the propofol-alone group (p=0.011).
Patients receiving the combination required significantly lower doses of propofol (p<0.0001).
Complex procedures like bronchoalveolar lavage or transbronchial biopsy showed greater benefit from the opiate combination.

Conclusions:

The combination of propofol and hydrocodone is a safe and effective option for cough suppression during flexible bronchoscopy.
This combination offers superior cough control compared to propofol alone, potentially reducing overall propofol requirements.