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Lipid profile, thyroid function, and serum magnesium level in type I diabetic children

R Derakhshan1, P Balaee, S Darakhshan

  • 1Department of Pediatrics, Rafsanjan University of Medical Sciences Rafsanjan, Iran. rderakhshan98@yahoo.com

Minerva Pediatrica
|February 12, 2011
PubMed

Insights

Type I diabetes in children is associated with altered thyroid function, specifically changes in TSH and T3 levels. Monitoring thyroid hormones is recommended for diabetic children.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Thyroidology

Background:

  • Type 1 diabetes mellitus (T1DM) is a chronic condition in children requiring careful management.
  • Understanding metabolic and hormonal changes in T1DM is crucial for optimal patient care.
  • Previous research has explored various biochemical markers in diabetic children, but thyroid function warrants further investigation.

Purpose of the Study:

  • To investigate alterations in lipid profiles, thyroid function (T3, T4, TSH), and magnesium (Mg) levels in children with type 1 diabetes.
  • To compare these parameters between children with T1DM and age-matched healthy controls.

Main Methods:

  • A descriptive cross-sectional study involving 50 children with T1DM and 50 healthy controls from Rafsanjan, Iran.
  • Data collection included demographic information, anthropometric measurements (height, weight, waist circumference), and biochemical analyses (blood glucose, lipid profile, Mg, thyroid hormones).

Main Results:

  • No significant differences were observed in body mass index (BMI), waist circumference, lipid profiles, or T4 levels between the groups.
  • Significant differences were found in mean T3 and serum TSH levels in children with T1DM compared to controls (P=0.046 and P=0.039, respectively).
  • Serum Mg levels were predominantly above 2 mg/dl in both groups, with no significant intergroup difference.

Conclusions:

  • Type 1 diabetes in children shows a significant association with altered serum TSH and T3 levels.
  • These findings suggest the importance of assessing thyroid hormone status in pediatric T1DM patients.
  • Regular monitoring of thyroid function may aid in the comprehensive management of type 1 diabetes in children.
Abstract

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