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Post-streptococcal acute glomerulonephritis: a clinical, bacteriological and serological study
1Department of Immunology, Tuberculosis Research Centre, Madras.
Indian Journal of Pediatrics
|November 1, 1990
Summary
Acute post-streptococcal glomerulonephritis (APSGN) in children typically follows skin infections like scabies or impetigo. This study found APSGN has an excellent prognosis, with no long-term proteinuria or hypertension observed in recovered children.
Area of Science:
- Pediatrics
- Nephrology
- Infectious Diseases
Background:
- Acute post-streptococcal glomerulonephritis (APSGN) is a significant pediatric renal disease.
- Infections, particularly skin infections, are common preceding conditions for APSGN.
Purpose of the Study:
- To investigate the clinical course and prognosis of APSGN in children.
- To identify the etiological agents and serological markers associated with APSGN.
Main Methods:
- Retrospective analysis of 864 children admitted with APSGN.
- Detailed investigation and 1-2 year follow-up of 135 children.
- Microbiological analysis for Group A beta-hemolytic streptococcus (BHS) and T-typing.
- Serological testing for anti-DNase B and ASO titres.
Main Results:
- Majority of APSGN cases followed infected scabies or impetigo.
- No proteinuria or hypertension was observed in children 2 years post-discharge.
- Group A BHS was isolated in 13.4% of patients; elevated anti-DNase B titres were common in patients and controls.
Conclusions:
- APSGN in children demonstrates an excellent prognosis with complete recovery.
- Skin infections are a primary trigger for APSGN.
- Anti-DNase B titres are a more reliable indicator than ASO titres in diagnosing APSGN associated with skin infections.