In vitro activity of certain antibiotics against dermatophytes

The in vitro effect of antibiotics i.e. Hamycin, Griseofulvin and Mycostatin against Microsporum gypseum and M. fulvum showed that hamycin was comparatively less inhibitory to M. fulvum. Complete inhibition in mycelial growth and sporulation of these two dermatophytes was observed by Mycostatin at its 1000 micrograms/ml conc. after 8 days. M. fulvum did not sporulate at higher concentration of griseofulvin. However, griseofulvin completely inhibited the sporulation in M. gypseum at all the concentration of this drug, but mycelial growth of M. fulvum and M. gypseum were significantly inhibited. Mycostatin was found more inhibitory to these dermatophytes in comparison to hamycin and griseofulvin.