[Hematotoxic and immunotoxic effects of nitrogen dioxide]
Related Experiment Video
Updated: Aug 18, 2026

Zebrafish as a Model to Assess the Teratogenic Potential of Nitrite
Published on: February 16, 2016
1Kliniki Hematologii Instytutu Medycyny Wewnetrznej AM w Krakowie.
Abstract:
The aim of the paper is to review hematological and immunological effects of experimental and occupational exposure to nitrogen dioxide (NO2). The NO2 exposure diminishes erythrocyte count, hemoglobin concentration and produces increased nitrosyl hemoglobin (NOHb) and methemoglobin (MetHb) concentrations in peripheral blood. The gas affects the activity of the membrane and glycolytic enzymes in erythrocytes. Experimental inhalation of NO2 results in an increased susceptibility to viral or bacterial infections. Moreover, the gas impairs phagocytic and bacteriocidal functions of alveolar macrophages. NO2 also causes lymphoid tissue damage reducing the thymus and spleen weight; it also diminishes specific antibody production and lymphocyte transformation in in vitro cultures with plant mitogens.
More Related Videos
05:46A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
08:23Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
Related Concept Videos
2° Amines to N-Nitrosamines: Reaction with NaNO2
Physical Properties of Amines
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Drug Toxicity: Dose-Dependent Reactions
Bioactivation and Tissue Toxicity