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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

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Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Cleaning agents and asthma.

S Quirce1, P Barranco

  • 1Allergy Department, Hospital La Paz Health Research Institute (IdiPAZ), Madrid, Spain. squirce@gmail.com

Journal of Investigational Allergology & Clinical Immunology
|February 15, 2011
PubMed
Summary
This summary is machine-generated.

Cleaning professionals face increased asthma risks due to chemical exposures. Identifying specific irritants and sensitizers in cleaning products is crucial for prevention.

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Area of Science:

  • Occupational health
  • Environmental toxicology
  • Respiratory medicine

Background:

  • Cleaners are a significant occupational group but understudied regarding health risks.
  • Epidemiological studies link cleaning work to asthma, yet risk factors remain unclear.
  • Exposure to cleaning product irritants, sensitizers, allergens, and pollutants is common.

Purpose of the Study:

  • To investigate the relationship between cleaning product exposure and asthma in cleaners.
  • To identify specific chemical irritants and sensitizers contributing to respiratory issues.
  • To explore mechanisms including irritant-induced asthma and specific sensitization.

Main Methods:

  • Review of epidemiological studies on cleaning work and asthma.
  • Analysis of chemical compositions of common cleaning products.
  • Identification of known respiratory irritants and sensitizers in cleaning agents.

Main Results:

  • Cleaning products contain sensitizers (disinfectants, quaternary ammonium compounds, amines, fragrances) and irritants (bleach, acids, alkaline agents).
  • Exposure can cause new-onset asthma, work-exacerbated asthma, and reactive airways dysfunction syndrome.
  • Prolonged exposure increases asthma risk; non-allergic airway symptoms and sensory hyperreactivity are also observed.

Conclusions:

  • Cleaning chemicals pose significant risks for asthma development and exacerbation in cleaners.
  • Understanding specific irritant and sensitizer roles is key to mitigating occupational asthma.
  • Airway sensory hyperreactivity may explain symptoms in some cleaners not attributable to asthma.