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Updated: Jun 4, 2026

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
Published on: October 23, 2019
Novel IkB kinase inhibitors for treatment of nuclear factor-kB-related diseases
Jun-ichi Suzuki1, Masahito Ogawa, Susumu Muto
1University of Tokyo, Graduate School of Medicine, Department of Advanced Clinical Science and Therapeutics, Tokyo, Japan.
Introduction:
NF-kB is a key regulator of inflammation and immunity in cancer development. The IkB kinase (IKK) is a multisubunit complex containing catalytic subunits termed IKK-α, -β and -γ. It is well known that many pro-inflammatory stimuli require the IKK-β subunit for NF-kB activation.
Areas Covered:
NF-kB affects the progression of inflammation-related diseases,such as myocardial ischemia, bronchial asthma, arthritis, cancer and other diseases. We review the characteristics and effects of these inhibitors on inflammatory and other diseases.
Expert Opinion:
Various synthesized IKK inhibitors have been developed and they will be used clinically in the near future.
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