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Updated: Jun 4, 2026
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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
[Study on experimental systemic lupus erythematosus mouse model induced by pristane]
Jin-Zhi Li1, Jun Ding, Boukherouba Merim
1Shanghai Institute of Immunology;Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
Summary
Pristane injection successfully models systemic lupus erythematosus (SLE) in mice, showing increased IFN-α producing cells and B cell activation, crucial for studying SLE pathogenesis.
Area of Science:
- Immunology
- Autoimmune Diseases
- Animal Models
Context:
- Systemic lupus erythematosus (SLE) is a complex autoimmune disease.
- Developing reliable animal models is crucial for understanding SLE pathogenesis.
- Pristane-induced mouse models offer a platform for SLE research.
Purpose:
- To establish a murine model of systemic lupus erythematosus (SLE) using pristane.
- To investigate the role of interferon-alpha (IFN-α) producing cells in SLE pathogenesis within this model.
- To analyze B cell activation and autoantibody production in pristane-treated mice.
Summary:
- Female BALB/c mice received a single intraperitoneal injection of pristane or PBS.
- Pristane treatment led to increased levels of total IgG, autoantibodies (anti-dsDNA, anti-sm RNP, anti-ribosomal P0), arthritis, and kidney damage.
- Elevated percentages of IFN-α producing cells and heightened B cell activation marker expression were observed in pristane-treated mice compared to controls.
Impact:
- Successfully established a pristane-induced mouse model for SLE research.
- Demonstrated the potential role of increased IFN-α producing cells in driving B cell abnormalities and SLE development.
- Provides a valuable tool for investigating SLE pathogenesis and evaluating potential therapeutic strategies.
