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Association between brachial-ankle pulse wave velocity and occult coronary artery disease detected by multi-detector

Hyo-Jung Nam1, In Hyun Jung, Jeongsoon Kim

  • 1Asan Heart Institute, University of Ulsan College of Medicine, Asan Medical Center, South Korea.

International Journal of Cardiology
|February 15, 2011
PubMed

Insights

Brachial-ankle pulse wave velocity (baPWV) is associated with cardiovascular disease risk factors and can help detect occult coronary artery disease (CAD) in asymptomatic individuals. A baPWV cutoff of 1426 cm/s shows promise for screening.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Diagnostic Imaging

Background:

  • Arterial stiffness, measured by pulse wave velocity (PWV), is a predictor of cardiovascular events.
  • The relationship between arterial stiffness and subclinical coronary artery disease (CAD) in asymptomatic individuals requires further investigation.

Purpose of the Study:

  • To assess the association between arterial stiffness (brachial-ankle PWV, baPWV) and occult CAD detected by multi-detector computed tomography (MDCT).
  • To determine the utility of baPWV as a screening tool for CAD in asymptomatic populations.

Main Methods:

  • Retrospective analysis of 615 asymptomatic South Korean individuals who underwent both baPWV and coronary CT angiography.
  • Correlation analysis between baPWV and cardiovascular risk factors, including coronary artery calcium score (CACS).
  • Comparison of baPWV values between subjects with and without significant CAD (stenosis >50%) on MDCT.

Main Results:

  • baPWV positively correlated with age, BMI, blood pressure, cholesterol, homocysteine, fasting glucose, and CACS.
  • Subjects with significant CAD had significantly higher baPWV (1573.2 cm/s) compared to those without (1409.6 cm/s).
  • An optimal baPWV cutoff of 1426.0 cm/s demonstrated 77% sensitivity and 63% specificity for detecting significant CAD, with an odds ratio of 3.30 for occult CAD after adjustment.

Conclusions:

  • baPWV is associated with cardiovascular risk factors and CACS in asymptomatic individuals.
  • A baPWV cutoff of 1426 cm/s is identified for detecting occult CAD via MDCT.
  • baPWV may serve as a valuable non-invasive screening tool for predicting occult CAD.
Abstract

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