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Type 2 diabetes and polymorphisms on chromosome 9p21: a meta-analysis
D Cugino1, F Gianfagna, I Santimone
1Laboratorio di Epidemiologia Genetica ed Ambientale, Laboratori di Ricerca, Centro di Ricerche e Formazione ad Alta Tecnologia nelle Scienze Biomediche Giovanni Paolo II, Università Cattolica del Sacro Cuore, Campobasso, Italy.
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|February 15, 2011
Summary
Genetic variants on chromosome 9p21 are associated with type 2 diabetes (T2D). The T allele of SNP rs10811661 significantly increases T2D risk by 21-27% in an additive manner.
Area of Science:
- Genetics
- Epidemiology
- Metabolic Diseases
Background:
- Genome-wide association studies (GWAS) have identified chromosome 9p21 variants linked to type 2 diabetes (T2D).
- The specific contribution and characteristics of these associations require further detailed investigation.
Purpose of the Study:
- To conduct a meta-analysis to precisely estimate the strength, accuracy, and features of the association between 9p21 polymorphisms and T2D.
- To quantify the population attributable risk (PAR) for identified T2D risk alleles.
Main Methods:
- Systematic retrieval of relevant publications from electronic databases and cross-referencing.
- Meta-analysis of data from 22 studies, including 38,455 T2D patients and 60,516 controls.
- Genotyping data for SNPs rs10811661, rs564398, rs10757278, and rs1333040; calculation of per-allele odds ratios (OR) and population attributable risk (PAR).
Main Results:
- The T allele of SNP rs10811661 showed a significant association with T2D across most studies (overall per-allele OR = 1.24, P < 10(-15)).
- Inheritance modeling indicated an additive effect for the T allele of rs10811661, with a PAR of 15% in Caucasians and 13% in Asians.
- SNP rs564398 demonstrated a weaker association (OR = 1.08, PAR = 6%), while other SNPs had negligible effects. No significant ethnic differences or substantial heterogeneity were observed.
Conclusions:
- This meta-analysis provides robust estimates for the association between 9p21 genetic variants and T2D risk.
- The T allele of rs10811661 plays a significant, albeit moderate, role in T2D susceptibility, increasing risk by 21-27% additively.
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