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Updated: Jun 4, 2026
Strategies for Study of Neuroprotection from Cold-preconditioning
Published on: September 2, 2010
Role of decoy molecules in neuronal ischemic preconditioning
Mathivadhani Panneerselvam1, Piyush M Patel, David M Roth
1Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92093, USA.
Aims:
Decoy receptors bind with TNF related apoptosis inducing ligands (TRAIL) but do not contain the cytoplasmic domains necessary to transduce apoptotic signals. We hypothesized that decoy receptors may confer neuronal protection against lethal ischemia after ischemic preconditioning (IPC).
Main Method:
Mixed cortical neurons were exposed to IPC one day prior to TRAIL treatment or lethal ischemia.
Key Findings:
IPC increased decoy receptor but reduced death receptor expression compared to lethal ischemia. IPC-induced increase in decoy receptor expression was reduced by prior treatment with CAPE, a nuclear factor-kappa B inhibitor (NFκB).
Significance:
Expression of decoy molecules, dependent on NFκB, may mediate neuronal survival induced by IPC.
