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Updated: Jun 4, 2026
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Temporal stability of defibrillation thresholds with cardiac resynchronization therapy
Michael R Gold1, Amir Hedayati, Jamshid Alaeddini
1Medical University of South Carolina, Charleston, South Carolina, USA. goldmr@musc.edu
Heart Rhythm
|February 15, 2011
Summary
Defibrillation thresholds (DFTs) remained stable in patients receiving cardiac resynchronization therapy (CRT), regardless of left ventricular reverse remodeling. This finding suggests CRT does not significantly impact DFTs over a six-month period.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Devices
Background:
- Defibrillation thresholds (DFTs) are generally stable in patients with implantable cardioverter-defibrillators (ICDs).
- The effect of cardiac resynchronization therapy (CRT) on DFTs has not been systematically investigated.
Purpose of the Study:
- To prospectively assess the impact of CRT and left ventricular (LV) reverse remodeling on DFTs.
Main Methods:
- A prospective, multicenter study of 54 CRT-defibrillator (CRT-D) patients.
- DFTs and echocardiograms were measured at implantation and 6 months post-implantation.
- LV reverse remodeling was defined as a >15% decrease in LV end-systolic volume.
Main Results:
- No significant changes in mean DFTs were observed at 6 months in either CRT responders or non-responders.
- DFT peak voltage, delivered energy, and shock impedance remained stable over the study period.
Conclusions:
- Cardiac resynchronization therapy does not alter defibrillation thresholds at 6 months.
- Left ventricular reverse remodeling in CRT patients does not affect DFT stability.
