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Published on: March 24, 2023
Superantigens in dermatology
Edgar S Macias1, Frederick A Pereira, William Rietkerk
1Department of Dermatology, New York Medical College, New York, New York 10029, USA. edgarmacias79@gmail.com
Abstract:
Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against SAgs. They are linked to a variety of conditions, ranging from toxic shock syndrome to recurrent toxin-mediated perineal erythema. The early recognition of signs and symptoms of SAg-mediated illnesses is important to ensure prompt medical treatment.
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