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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...

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Related Experiment Video

Updated: Jun 4, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

DEK expression in melanocytic lesions.

Ferdinand Kappes1, Michael S Khodadoust, Limin Yu

  • 1Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109-0602, USA.

Human Pathology
|February 15, 2011
PubMed
Summary

DEK oncogene expression is low in benign nevi and melanoma in situ but significantly higher in invasive melanomas. Increased DEK expression correlates with melanoma depth and metastasis, suggesting its role in melanoma progression.

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Last Updated: Jun 4, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry
09:52

Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry

Published on: November 25, 2011

Area of Science:

  • Oncology
  • Dermatology
  • Molecular Biology

Background:

  • Malignant melanoma diagnosis is challenging, relying on histopathology.
  • The DEK oncogene, a chromatin-bound factor, is implicated in melanoma development and progression.
  • Understanding DEK's role is crucial for advancing melanoma diagnosis and treatment.

Purpose of the Study:

  • To investigate DEK oncogene expression levels across various melanocytic lesions.
  • To determine the correlation between DEK expression and melanoma progression, including depth and metastasis.

Main Methods:

  • Immunohistochemistry was used to assess DEK expression.
  • A total of 147 melanocytic lesions were analyzed, including nevi, melanoma in situ, primary invasive melanomas, and metastatic melanomas.

Main Results:

  • DEK expression was low in benign nevi and melanoma in situ.
  • Significantly higher DEK expression was observed in primary invasive melanomas compared to benign nevi (P < .0001).
  • DEK expression increased with melanoma depth (Breslow >1 mm) and in metastatic lesions (P < .05).

Conclusions:

  • DEK overexpression is a frequent event in invasive melanomas.
  • Elevated DEK expression is associated with advanced melanoma features like deep invasion and metastasis.
  • DEK plays a significant role in melanoma progression.