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4-aminopyrimidine-5-carbaldehyde oximes as potent VEGFR-2 inhibitors. Part II
Shenlin Huang1, Ronghua Li, Kenneth R LaMontagne
1Johnson & Johnson Pharmaceutical Research & Development LLC, Raritan, NJ 08869, USA. shenlinhuang@hotmail.com
Bioorganic & Medicinal Chemistry Letters
|February 15, 2011
Abstract:
A series of 4-aminopyrimidine-5-carbaldehyde oxime was discovered to have potent VEGFR-2 inhibitory activity. Described here are the chemistry for analogue synthesis and SAR study results. The PK properties, kinase profiling, and in vivo efficacy study for compound 4b are also discussed.
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