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Related Concept Videos

Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
Prokaryotic Gene Structure and Organization01:28

Prokaryotic Gene Structure and Organization

Prokaryotic genomes exhibit a streamlined organization of coding and non-coding regions essential for gene expression and protein synthesis. While coding regions contain the genetic instructions for proteins or functional RNAs, non-coding regions regulate the precise transcription and translation of these genes.Coding Regions: Proteins and RNAsThe primary coding regions, known as structural genes, include sequences transcribed into messenger RNA (mRNA) and ultimately translated into...
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Organization of Genes02:07

Organization of Genes

Overview

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Genome-wide Snapshot of Chromatin Regulators and States in Xenopus Embryos by ChIP-Seq
10:23

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Published on: February 26, 2015

eGOB: eukaryotic Gene Order Browser.

Marcela Dávila López1, Tore Samuelsson

  • 1Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, SE-405 30 Göteborg, Sweden.

Bioinformatics (Oxford, England)
|February 15, 2011
PubMed
Summary
This summary is machine-generated.

The eukaryotic Gene Order Browser offers comparative genomics insights by visualizing gene order across 74 species. This tool aids in studying gene organization evolution and conserved gene pairs.

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Area of Science:

  • Comparative genomics
  • Bioinformatics
  • Evolutionary biology

Background:

  • The increasing availability of sequenced eukaryotic genomes facilitates comparative studies.
  • Gene order and organization are crucial aspects of genome evolution.

Purpose of the Study:

  • To present the eukaryotic Gene Order Browser (eGOB) for exploring gene order across diverse species.
  • To enable examination of gene organization evolution and non-random gene order patterns.
  • To provide access to data on evolutionarily conserved adjacent gene pairs.

Main Methods:

  • Development of a web-based browser integrating gene order data.
  • Inclusion of gene order information for 74 eukaryotic species, covering both protein-coding and non-coding RNA genes.
  • Functionality to display a gene of interest within its genomic context across multiple species.

Main Results:

  • The browser visualizes the genomic context of specific genes in 74 eukaryotic species.
  • It facilitates comparative analysis of gene order and organization.
  • Data on conserved adjacent gene pairs is accessible for evolutionary studies.

Conclusions:

  • The eukaryotic Gene Order Browser is a valuable resource for evolutionary and comparative genomics research.
  • It supports investigations into the evolution of gene organization and conserved synteny.
  • The tool enhances the study of genome evolution through accessible gene order data.