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[New route of 2-N-(carboxypropylamino)-2-deoxy-D-glucopyranose synthesis]
R Couffignal1, F Dardoize, C Goasdoue
1Laboratoire de Chimie des Médiateurs Moléculaires, Université Pierre et Marie Curie, Paris.
Annales Pharmaceutiques Francaises
|January 1, 1990
Abstract:
A new route to 2-N-(carboxypropylamino)-2-deoxy-D-glucopyranose synthesis is reported, involving the Schiff-base derivative of beta-D-glucosamine with benzyl 4-oxobutyrate. Improvement in the synthesis of benzyl-4-oxobutyrate is also described. Biological compounds action was investigated by evaluating sedative and dopaminergic activities on male mice.