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Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

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Published on: November 12, 2015

Illumination system for corneal collagen crosslinking.

Matthew Sheehan¹, Bill Watson, Alexander Goncharov

¹National University Ireland-Galway, Galway, Ireland. sheehan.matthew@gmail.com

Optometry and Vision Science : Official Publication of the American Academy of Optometry

|February 15, 2011

Summary

A new ultraviolet illumination system enhances corneal collagen crosslinking (CXL) for treating conditions like keratoconus. This safe and effective system optimizes UV light delivery for improved patient outcomes.

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Area of Science:

Ophthalmology
Biomedical Engineering
Optics

Background:

Corneal collagen crosslinking (CXL) treats keratectasia, including keratoconus and pellucid marginal degeneration.
CXL relies on a photosensitizer (Riboflavin) activated by UV light to strengthen corneal collagen.

Purpose of the Study:

To design and construct a novel ultraviolet (UV) illumination system for CXL procedures.
To ensure safe and effective delivery of UV light at Riboflavin's absorption peak.

Main Methods:

Raytracing simulations were employed to evaluate various optical designs.
The system's mechanical mounting and beam testing apparatus were developed.
Design compromises were analyzed for clinical safety and practicality.

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Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

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Last Updated: Jun 4, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

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Published on: November 12, 2015

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking (TXL) for Myopia

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Published on: January 6, 2018

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

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Main Results:

The system provides uniform treatment effect over the desired corneal diameter.
Optical design enhances beam control and safety compared to basic systems.
A cost-effective prototype was constructed with integrated mounting and testing.

Conclusions:

The developed UV illumination system offers a balanced approach to CXL.
It addresses both clinical efficacy and patient eye safety concerns.