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A prospective study of parainfluenza virus type 4 infections in children attending daycare

Mary P Fairchok1, Emily T Martin, Jane Kuypers

  • 1Department of Pediatrics, Madigan Army Medical Center, Tacoma, WA 98431, USA. mary.fairchok@us.army.mil

The Pediatric Infectious Disease Journal
|February 15, 2011
PubMed

Insights

Parainfluenza virus type 4 (PIV-4) is common in young children, detected using PCR. PIV-4 infections were frequent and not more severe than other PIV types.

Area of Science:

  • Pediatric infectious diseases
  • Virology
  • Respiratory infections

Background:

  • Parainfluenza virus type 4 (PIV-4) research is limited due to culture difficulties.
  • Understanding PIV-4 epidemiology in young children is crucial.

Purpose of the Study:

  • To determine the incidence and clinical presentation of PIV-4 in a daycare cohort.
  • To compare PIV-4 severity with other parainfluenza virus types.

Main Methods:

  • Prospective cohort study of 225 young children over 165 child-years.
  • Polymerase chain reaction (PCR) used to detect 12 respiratory viruses, including PIV-4.
  • Clinical data collected to assess illness severity and syndrome.

Main Results:

  • PIV-4 was the second most common parainfluenza virus, detected in 10% of PIV-positive illnesses.
  • PIV-4 infections occurred in 9 of 87 PIV+ illnesses.
  • PIV-4 associated illnesses showed no increased severity or specific clinical syndrome.

Conclusions:

  • PIV-4 is a significant contributor to respiratory illness in young children attending daycare.
  • PCR-based detection is effective for studying PIV-4.
  • PIV-4 does not appear to cause more severe disease than other PIV types.

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