Related Experiment Video
Updated: Aug 12, 2026

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
Published on: January 27, 2013
[Acute pharmacokinetics of the Tl+ ion in the rabbit. 3-compartment model]
A Morales-Aguilera1, J Careaga Olivares
1División de Farmacología, Unidad de Investigación Biomédica del Noreste, IMSS, Monterrey, N.L., México.
Abstract:
New Zealand rabbits were used to determine the acute kinetics of the Tl+ ion (0 to 90 minutes) following intravenous administration of two doses of Tl+ (10 mg.kg-1 and 30 mg.kg-1). The rapid disappearance of Tl+ from the blood may be explained by means of an open parallel tricompartmental mamillary model. The most important pharmacokinetic parameters which changed with the dose were Vdl (0.61 +/- 0.08 1.kg-1 for the low dose and 0.59 +/- 0.10 1.kg-1 for the high dose); ABC0-90 (310 +/- 18 mg.ml-1 min-1 for the low dose and 942 +/- 107 Mg.ml-1 min for the high dose; Kd (0.026 +/- 0.005 min-1 for the low dose and 0.037 +/- 0.010 min-1 for the high dose). The importance of the values of the slopes alpha, rho & gamma found by residual methods are discussed and compared with the results reported by other authors working with other species and different times.
Related Concept Videos
Compartment Models: Two-Compartment Model
One-Compartment Open Model for IV Bolus Administration: General Considerations
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant, half-life,...
One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution
Two-Compartment Open Model: IV Bolus Administration
The disparity between drug input and the sum of drug transfer rates between...
Two-Compartment Open Model: Extravascular Administration
The absorption exponent (ka) indicates the speed at which the drug is...
Three-Compartment Open Model

