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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
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Primary Symptoms of COPD:
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
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Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

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Related Experiment Video

Updated: Jun 4, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Psoriasis: comorbidities and associations.

E Farley1, A Menter

  • 1Department of Dermatology, Baylor University Medical Center, Dallas, TX 75246, USA.

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia
|February 15, 2011
PubMed
Summary
This summary is machine-generated.

Psoriasis, a chronic inflammatory skin disease, is linked to serious health issues like heart disease and increased mortality risk, especially in younger patients. Systemic inflammation plays a key role in these associated conditions.

Related Experiment Videos

Last Updated: Jun 4, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Psoriasis affects 2% of the global population as a chronic, genetic, inflammatory skin condition.
  • Research indicates associations between psoriasis and psoriatic arthritis, depression, substance abuse, obesity, diabetes, heart disease, and stroke.
  • Younger psoriasis patients, particularly those with severe disease, face elevated mortality risks, even after accounting for comorbidities.

Purpose of the Study:

  • To discuss the associations between psoriasis and various systemic health problems.
  • To highlight the role of systemic inflammation in psoriasis comorbidities.
  • To underscore the increased morbidity and mortality risks in psoriasis patients.

Main Methods:

  • Literature review of studies on psoriasis and associated systemic conditions.
  • Analysis of the role of inflammatory markers in psoriasis pathophysiology.
  • Examination of epidemiological data on psoriasis prevalence and mortality.

Main Results:

  • Psoriasis is associated with psoriatic arthritis, mental health issues, and substance abuse.
  • Patients with psoriasis exhibit a higher incidence of obesity, diabetes, cardiovascular events, and stroke.
  • Systemic inflammation, indicated by elevated C-reactive protein and cytokines (e.g., TNF-a, IL-6, IL-17), contributes to psoriasis-related morbidity and mortality.

Conclusions:

  • Psoriasis is a systemic disease with significant implications beyond the skin.
  • Inflammatory pathways are crucial in understanding the comorbidities and mortality associated with psoriasis.
  • Comprehensive management of psoriasis should address its systemic effects and associated health risks.