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Updated: Jun 4, 2026
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Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
Published on: August 15, 2025
Parotid and temporal bone resection for skull base malignancies: outcome
Zoukaa Sargi1, Robert Gerring, Simon Angeli
1Division of Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, Florida.
Summary
Advanced lateral skull base malignancies treated with combined resection showed a 42.6-month disease-free survival. Temporal bone erosion on CT and tumor histology are key prognostic factors.
Area of Science:
- Oncology
- Surgical Oncology
- Otolaryngology
Background:
- Advanced lateral skull base malignancies pose significant treatment challenges.
- Combined surgical approaches are often necessary for managing these complex tumors.
Purpose of the Study:
- To review the outcomes of patients undergoing combined lateral skull base resection.
- To identify prognostic factors influencing survival in these patients.
Main Methods:
- Retrospective, single-institution case series.
- Inclusion of 79 patients with combined temporal bone resection and parotidectomy.
- Analysis of overall survival and disease-free survival.
Main Results:
- Mean follow-up was 18.3 months; overall survival was 64.5 months, disease-free survival was 42.6 months.
- Disease-free survival varied by histology: 36.2 months (skin), 42.7 months (salivary), 8.5 months (mesenchymal).
- Temporal bone erosion on CT (p=0.009) and histology (p=0.045) were significant predictors of poor outcome.
Conclusions:
- Combined lateral temporal bone resection and parotidectomy is an effective management strategy.
- Malignant mesenchymal tumors and preoperative temporal bone erosion are associated with a poor prognosis.
