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Related Concept Videos

Ribosomes

Ribosomes

Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome production. Within...

Ribosomes

Ribosomes

Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.Ribosome Structure and AssemblyRibosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome production. Within the...

Ribosomes

Ribosomes

Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome production. Within...

Ribosomes

Ribosomes

Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.Ribosome Structure and AssemblyRibosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome production. Within the...

Ribosomal RNA Synthesis

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...

Ribosomal RNA Synthesis

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...

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Related Experiment Video

Updated: Jun 4, 2026

Single Molecule Fluorescence Energy Transfer Study of Ribosome Protein Synthesis

Single Molecule Fluorescence Energy Transfer Study of Ribosome Protein Synthesis

Published on: July 6, 2021

The small subunit processome in ribosome biogenesis—progress and prospects.

Kathleen R Phipps¹, J Michael Charette, Susan J Baserga

¹Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA.

Wiley Interdisciplinary Reviews. RNA

|February 15, 2011

Summary

The small subunit (SSU) processome, crucial for ribosome assembly, involves many protein and RNA factors. Identifying these components reveals how they form subcomplexes, advancing our understanding of SSU biogenesis.

Keywords:

RNA chaperone RNA processing SSU processome U3 snoRNA Utp ribosomal SSU

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Area of Science:

Molecular Biology
Cell Biology
Biochemistry

Background:

The small subunit (SSU) processome is a large ribonucleoprotein complex essential for eukaryotic ribosome biogenesis.
Decades of research have identified numerous factors involved in SSU processing, assembly, and maturation.
Despite progress, the intricate molecular mechanisms and factor interactions remain complex and incompletely understood.

Purpose of the Study:

To review the current understanding of SSU processome components and their roles in ribosome biogenesis.
To highlight how identifying individual components has led to insights into their assembly into functional subcomplexes.
To explore the impact of subcomplex knowledge on understanding the overall ribosome synthesis system, particularly for the small ribosomal subunit.

Main Methods:

Literature review focusing on component identification in SSU biogenesis.
Analysis of how protein and RNA factors associate to form subcomplexes.
Synthesis of knowledge regarding subcomplex assembly and its contribution to ribosome maturation.

Main Results:

Identification of numerous protein and RNA factors constituting the SSU processome.
Elucidation of how these factors interact and assemble into distinct subcomplexes.
Demonstration that understanding subcomplex formation is key to comprehending the entire SSU biogenesis pathway.

Conclusions:

Cataloging SSU processome components is fundamental to understanding ribosome synthesis.
The assembly of factors into subcomplexes provides critical insights into the stepwise maturation of the SSU.
Knowledge of subcomplexes significantly advances our comprehension of eukaryotic ribosome biogenesis and function.