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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Related Experiment Video

Updated: Jan 1, 2026

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
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Immunotherapy for lung cancers.

Ming-Yi Ho1, Shye-Jye Tang, Kuang-Hui Sun

  • 1Department of Biotechnology, and Laboratory Science in Medicine, National Yang-Ming University, Taipei 11221, Taiwan.

Journal of Biomedicine & Biotechnology
|February 15, 2011
PubMed
Summary
This summary is machine-generated.

Lung cancer immunotherapy shows promise, but tumor cells can evade immune responses. Further understanding of immune evasion mechanisms is crucial for developing more effective lung cancer treatments.

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Area of Science:

  • Oncology
  • Immunology

Background:

  • Lung cancer remains a leading cause of cancer mortality globally.
  • Current treatments like surgery, irradiation, and chemotherapy offer limited efficacy.
  • Novel therapeutic strategies, particularly immunotherapy, are urgently needed.

Purpose of the Study:

  • To discuss tumor antigen identification in lung cancer.
  • To explore tumor immune evasion mechanisms.
  • To review clinical vaccine trials for lung cancer.

Main Methods:

  • Review of existing literature on lung cancer immunotherapy.
  • Analysis of tumor antigen identification strategies.
  • Examination of immune evasion pathways utilized by lung cancer cells.
  • Compilation of data from clinical vaccine trials.

Main Results:

  • Immunotherapy, including cancer vaccines, has shown potential in prolonging survival in clinical trials.
  • Many current immunotherapies are effective only in a subset of patients.
  • Tumor cells possess mechanisms to evade host immune surveillance, limiting treatment effectiveness.

Conclusions:

  • Developing effective immunotherapies requires a deeper understanding of tumor antigen identification and immune evasion.
  • Further research into overcoming immune evasion is essential for advancing lung cancer treatment.
  • Clinical trials are ongoing to improve the efficacy of lung cancer vaccines and immunotherapies.