Related Experiment Video

Updated: Aug 11, 2026

Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation
14:21

Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation

Published on: January 22, 2013

[The problems of clinico-morphological diagnosis in a case of fatal hemoptysis]

C Marica1, P Galbenu

  • 1Clinica de Ftiziologie, I.M.F. Bucureşti.

Revista De Igiena, Medicina Muncii, Medicina Sociala, Bacteriologie, Virusologie, Parazitologie, Epidemiologie, Pneumoftiziologie. Pneumoftiziologie
|April 1, 1990
PubMed

Insights

Pulmonary function tests in children with bronchial asthma show significant variability, especially for airway resistance (Raw) and maximum expiratory flows (MEF50). The vital capacity/maximum expiratory volume per second ratio offers limited insight into obstructive syndrome severity.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Clinical Physiology

Background:

  • Bronchial asthma is a chronic respiratory condition affecting children, characterized by airway inflammation and hyperresponsiveness.
  • Accurate assessment of pulmonary function is crucial for monitoring asthma severity and guiding treatment in pediatric patients.
  • Longitudinal studies evaluating the variability of pulmonary function parameters in children with asthma are essential for understanding disease dynamics.

Observation:

  • This study followed 28 children (6-18 years) with bronchial asthma over 3 months to 5 years, assessing pulmonary function during asymptomatic, manifest, and crisis phases.
  • Functional pulmonary investigations included spirometry (VC, MEVS, VC/MEVS ratio), plethysmography (VGT, Raw), and MEF50 measurements.
  • Data were analyzed for average values, standard deviation, and variation coefficients across different clinical states.

Findings:

  • Pulmonary function parameters in children with bronchial asthma exhibited broad variations (2.9%-11.5%) during repeated examinations.
  • Airway resistance (Raw) showed the widest variation, followed by maximum expiratory flows (MEF50).
  • The vital capacity/maximum expiratory volume per second (VC/MEVS) ratio demonstrated the least variation, suggesting limited utility in assessing obstructive syndrome severity.

Implications:

  • Understanding the variability of pulmonary function tests is vital for interpreting results in pediatric asthma management.
  • Airway resistance (Raw) and MEF50 are more sensitive indicators of dynamic changes in obstructive lung disease in children.
  • The limited information from the VC/MEVS ratio highlights the need for comprehensive pulmonary function assessment in pediatric asthma.

More Related Videos

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice07:38

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

Published on: April 13, 2018

Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells08:54

Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells

Published on: May 20, 2020

Related Concept Videos

Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...