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The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity
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The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

Published on: December 14, 2016

Aging affects human B cell responses.

Daniela Frasca1, Bonnie B Blomberg

  • 1Department of Microbiology and Immunology, University of Miami Miller School of Medicine, RMSB 3146A, P.O. Box 016960(R-138), Miami, FL 33101, USA. dfrasca@med.miami.edu

Journal of Clinical Immunology
|February 15, 2011
PubMed
Summary
This summary is machine-generated.

Aging impairs immune responses, particularly in the elderly. This study highlights how age-related changes in B cells contribute to reduced vaccine effectiveness, like with the influenza vaccine.

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Area of Science:

  • Immunology
  • Gerontology
  • Vaccinology

Background:

  • Aging leads to a decline in both innate and adaptive immunity.
  • Reduced vaccine responses in older adults are linked to age-related humoral immunity changes.
  • While T cell alterations are known, B cell changes also impact immune function with age.

Purpose of the Study:

  • To provide an overview of age-related alterations in B cell markers and functions.
  • To investigate the contribution of intrinsic B cell changes to diminished antibody production in aging individuals.

Main Methods:

  • Review of age-related changes in B cell markers.
  • Functional assessment of B cells in aging.
  • Analysis of antibody responses post-vaccination in elderly populations.

Main Results:

  • Significant age-related changes in B cell populations and their functions were observed.
  • Intrinsic alterations in B cells were identified as a key factor in reduced antibody responses.
  • These B cell changes correlate with decreased effectiveness of vaccines, such as the influenza vaccine.

Conclusions:

  • Intrinsic B cell aging contributes significantly to impaired humoral immunity.
  • Understanding these B cell changes is crucial for improving vaccine strategies in the elderly.
  • Further research into B cell modulation could enhance immune protection in aging populations.