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Designing Animal Models of Alzheimer's Disease with Amyloid Precursor Protein (APP) Transgenes

J F Loring1

  • 1Incyte Pharmaceuticals, Inc, Palo Alto, CA.

Methods in Molecular Medicine
|February 15, 2011
PubMed

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Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...