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Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

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Related Experiment Video

Updated: Jun 4, 2026

In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium
10:18

In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium

Published on: May 6, 2018

Renal gene therapy.

Y H Lien1, L W Lai

  • 1Department of Medicine, University of Arizona Health Sciences Center, Tucson, AZ.

Methods in Molecular Medicine
|February 15, 2011
PubMed
Summary
This summary is machine-generated.

Nonviral gene therapy shows promise for treating kidney diseases, with various delivery routes enhancing its potential. This review explores nonviral methods for renal gene therapy and their safety.

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Hydrodynamic Renal Pelvis Injection for Non-viral Expression of Proteins in the Kidney
08:26

Hydrodynamic Renal Pelvis Injection for Non-viral Expression of Proteins in the Kidney

Published on: January 8, 2018

Related Experiment Videos

Last Updated: Jun 4, 2026

In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium
10:18

In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium

Published on: May 6, 2018

Hydrodynamic Renal Pelvis Injection for Non-viral Expression of Proteins in the Kidney
08:26

Hydrodynamic Renal Pelvis Injection for Non-viral Expression of Proteins in the Kidney

Published on: January 8, 2018

Area of Science:

  • Nephrology
  • Molecular Biology
  • Biotechnology

Background:

  • Clinical renal gene therapy is currently unavailable, despite promising experimental results for various kidney diseases.
  • The kidney's complex structure (vascular, glomerular, tubular, interstitial) and physiological factors influence gene therapy efficacy.
  • The kidney offers multiple accessible delivery routes, including intrarenal artery infusion and direct injection.

Purpose of the Study:

  • To review nonviral gene transfer methods for different kidney compartments.
  • To discuss gene therapy in skeletal muscle for renal applications.
  • To explore potential applications and safety concerns of renal gene therapy.

Main Methods:

  • Review of existing literature on nonviral gene transfer in renal compartments.
  • Examination of gene transfer in skeletal muscle for renal gene therapy.
  • Analysis of potential applications and safety considerations.

Main Results:

  • Nonviral gene transfer has been tested in various kidney compartments with promising outcomes.
  • Skeletal muscle can be utilized for renal gene therapy applications.
  • Several delivery routes enhance the accessibility and potential efficacy of renal gene therapy.

Conclusions:

  • Nonviral gene therapy presents a viable strategy for treating renal diseases.
  • Further research into applications and safety is crucial for clinical translation.
  • The kidney's accessibility and compartmentalization offer unique opportunities for gene therapy development.