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Related Experiment Video

Updated: Jun 4, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

Expression of c-met and WT-1.

L Kushner¹, P Y Chiu, P Pinto

¹Department of Urology, Long Island Jewish Medical Center, New Hyde Park, NY.

Methods in Molecular Medicine

|February 15, 2011

Summary

Protooncogenes and tumor-suppressor genes are critical gene types involved in cancer development. Understanding their roles is key to cancer research and potential therapies.

Area of Science:

Oncology
Molecular Biology
Genetics

Background:

Cancer development involves genetic alterations.
Protooncogenes and tumor-suppressor genes are key players in cell growth regulation.

Purpose of the Study:

To elucidate the distinct roles of protooncogenes and tumor-suppressor genes in oncogenesis.
To provide a foundational understanding of these gene classes for cancer research.

Main Methods:

Literature review of genetic mechanisms in cancer.
Analysis of gene function in cellular proliferation and apoptosis.

Main Results:

Protooncogenes, when mutated, can drive uncontrolled cell growth.
Tumor-suppressor genes normally inhibit cell division; their inactivation contributes to cancer.

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The Soft Agar Colony Formation Assay

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Last Updated: Jun 4, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

The Soft Agar Colony Formation Assay

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

Conclusions:

Both protooncogenes and tumor-suppressor genes are fundamentally linked to cancer etiology.
Dysregulation of these gene types represents a core mechanism in tumorigenesis.