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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jun 4, 2026

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System

Published on: August 30, 2019

Murine animal model.

N Nishisaka¹, P Morse, R F Jones

¹Department of Urology, State University of New York Health Science Center at Syracuse and VA Medical Center, Syracuse, NY.

Methods in Molecular Medicine

|February 15, 2011

Summary

This summary is machine-generated.

The Renca murine model offers a valuable platform for studying renal carcinoma treatments. This model facilitates research into chemotherapy, immunotherapy, and radiotherapy efficacy and safety in mice.

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Area of Science:

Oncology
Immunology
Animal Models

Background:

Murine models are advantageous for evaluating treatment efficacy and safety due to ease of handling and scalability.
The Renca (renal carcinoma) model in Balb/c mice is frequently utilized for preclinical cancer research.
Renca cells form orthotopic tumors with predictable growth, mimicking clinical renal adenocarcinoma and metastasis.

Purpose of the Study:

To describe experimental systems utilizing the Renca murine model for cancer research.
To highlight the utility of the Renca model in assessing chemotherapy, immunotherapy, and radiotherapy.
To emphasize the Renca model's contribution to understanding antitumor immune responses.

Main Methods:

Utilizing spontaneous murine renal carcinoma (Renca) in Balb/c mice.
Establishing orthotopic tumors for assessment of treatment modalities.
Employing cytokine gene-modified tumor vaccines (e.g., interferon-alpha, interleukin-2).

Main Results:

Renca model provides histologically proven adenocarcinoma with predictable growth rates.
The model supports the evaluation of chemotherapy, immunotherapy, and radiotherapy.
Growing use of Renca for immunotherapy studies, particularly with cytokine gene modification.

Conclusions:

The Renca murine model is a robust system for preclinical evaluation of renal carcinoma treatments.
This model aids in analyzing antitumor immune response mechanisms.
Renca experiments are crucial for advancing cancer therapy research.