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Related Concept Videos

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

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Related Experiment Video

Updated: Jun 4, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Mutation Detection inTGF-β Receptors.

W M Grady1, L L Myeroff, H He

  • 1Ireland Cancer Center, University Hospitals of Cleveland, Cleveland, OH.

Methods in Molecular Medicine
|February 15, 2011
PubMed
Summary
This summary is machine-generated.

Transforming growth factor β (TGF-β) receptors are key tumor suppressors. Cancer cells often develop resistance to TGF-β

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Last Updated: Jun 4, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Visualizing Genetic Variants, Short Targets, and Point Mutations in the Morphological Tissue Context with an RNA In Situ Hybridization Assay
10:57

Visualizing Genetic Variants, Short Targets, and Point Mutations in the Morphological Tissue Context with an RNA In Situ Hybridization Assay

Published on: August 14, 2018

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Transforming growth factor β (TGF-β) receptors function as critical tumor suppressors.
  • TGF-β normally inhibits epithelial cell growth, but many cancers exhibit resistance.
  • This resistance is linked to disruptions in TGF-β signal transduction pathways.

Purpose of the Study:

  • To investigate the molecular mechanisms underlying TGF-β resistance in cancer.
  • To identify key genetic alterations contributing to impaired TGF-β signaling.

Main Methods:

  • Analysis of cancer cell lines exhibiting resistance to TGF-β.
  • Examination of mutations within TGF-β receptors and associated signaling proteins.

Main Results:

  • Many cancer cell lines demonstrate resistance to the growth-inhibitory effects of TGF-β.
  • Disrupted TGF-β signal transduction is evident in resistant cancer cells.
  • Mutations in TGF-β receptors and smad proteins are frequently observed.

Conclusions:

  • Mutations in TGF-β receptors or smad proteins are a common cause of TGF-β resistance in cancer.
  • Understanding these mutations is crucial for developing targeted cancer therapies.