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Published on: June 16, 2013
Inhibition of tumor blood flow
C Lai-Ming1, W R Wilson, B C Baguley
1Cancer Research Laboratory, University of Auckland School of Medicine, Auckland, New Zealand.
Tumor blood vessel development is disorganized, offering a potential target for cancer therapy. This review explores methods to inhibit tumor blood flow and measure its impact.
Area of Science:
- Oncology
- Vascular Biology
Background:
- Cancer research historically sought universal biochemical targets.
- Genetic heterogeneity of individual tumors is now recognized.
- Disorganized tumor vasculature is a common feature across solid tumors.
Purpose of the Study:
- To review the vasculature of solid tumors.
- To describe methods for inhibiting tumor blood flow.
- To review methods for measuring tumor blood flow.
Main Methods:
- Review of existing literature on tumor vasculature.
- Description of anti-angiogenic drug strategies.
- Overview of techniques for assessing tumor hemodynamics.
Main Results:
- Tumor capillaries exhibit haphazard structure and dynamics compared to normal tissue.
- Inhibiting tumor blood flow presents a viable therapeutic strategy.
- Various methods exist for quantifying tumor blood flow.
Conclusions:
- The unique vascularization of solid tumors provides a potential therapeutic target.
- Targeting tumor angiogenesis may offer selective cancer treatment.
- Accurate measurement of tumor blood flow is crucial for evaluating treatment efficacy.
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