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Updated: Jun 4, 2026

Preparation and Use of HIV-1 Infected Primary CD4+ T-Cells as Target Cells in Natural Killer Cell Cytotoxic Assays

Preparation and Use of HIV-1 Infected Primary CD4+ T-Cells as Target Cells in Natural Killer Cell Cytotoxic Assays

Published on: March 14, 2011

11 Targeting HIV-Infected Cells.

¹Department of Microbiology, Montana State University, Bozeman, MT.

Methods in Molecular Medicine

|February 15, 2011

Summary

This summary is machine-generated.

Targeted delivery methods for human immunodeficiency virus (HIV)-infected cells are discussed. Monoclonal antibodies are explored for delivering agents like toxins, antiviral drugs, liposomes, and genes specifically to infected cells for therapy or research.

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Last Updated: Jun 4, 2026

Preparation and Use of HIV-1 Infected Primary CD4+ T-Cells as Target Cells in Natural Killer Cell Cytotoxic Assays

Preparation and Use of HIV-1 Infected Primary CD4+ T-Cells as Target Cells in Natural Killer Cell Cytotoxic Assays

Published on: March 14, 2011

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Specific Marking of HIV-1 Positive Cells using a Rev-dependent Lentiviral Vector Expressing the Green Fluorescent Protein

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Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

Assessing the Innate Sensing of HIV-1 Infected CD4⁺ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

Published on: September 1, 2015

Area of Science:

Biomedical science
Virology
Drug delivery systems

Background:

Human immunodeficiency virus (HIV) infection requires effective therapeutic strategies.
Current methods for delivering agents to HIV-infected cells face challenges with specificity.
Non-specific delivery can lead to inhibition of cellular processes and off-target effects.

Purpose of the Study:

To describe methods for targeted delivery of agents to HIV-infected cells.
To explore strategies for enhancing therapeutic or experimental efficacy against HIV.
To review approaches that overcome the limitations of non-specific drug delivery.

Main Methods:

Utilizing agents that are activated specifically within HIV-infected cells.
Employing strategies to target delivery systems directly to infected cells.
Using monoclonal antibodies (MAbs) for targeted delivery of toxins, antiviral agents, liposomes, and genes.

Main Results:

Monoclonal antibodies have been successfully used to deliver toxins to HIV-infected cells.
This targeted approach offers improved specificity compared to non-specific delivery methods.
The chapter outlines the potential for delivering various therapeutic payloads via targeted delivery.

Conclusions:

Targeted delivery systems, particularly those using monoclonal antibodies, show promise for treating HIV infection.
Specificity in agent delivery is crucial for maximizing therapeutic benefit and minimizing side effects.
Further research into targeted delivery methods can advance HIV therapeutics and experimental research.