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Related Concept Videos

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Gastritis-I: Introduction and Types01:27

Gastritis-I: Introduction and Types

Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...

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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

Preliminary study comparing diffuse gastric FDG uptake and gastritis.

Seiei Yasuda1, Masahiko Takechi, Kazuhiro Ishizu

  • 1Department of Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan. yasuda@is.icc.u-tokai.ac.jp

The Tokai Journal of Experimental and Clinical Medicine
|February 15, 2011
PubMed
Summary

Gastritis, an inflammation of the stomach lining, is a primary cause of diffuse fluorodeoxyglucose (FDG) uptake observed in positron emission tomography (PET) scans. This finding clarifies a previously undetermined cause of gastric FDG accumulation in patients undergoing PET imaging.

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Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
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Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
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Area of Science:

  • Nuclear Medicine
  • Gastroenterology
  • Oncology Imaging

Background:

  • Diffuse high fluorodeoxyglucose (FDG) uptake in the stomach on positron emission tomography (PET) scans is occasionally observed.
  • The exact cause of this gastric FDG uptake is undetermined, with some oncologists considering it physiologic.
  • Understanding the cause is crucial for accurate interpretation of PET/computed tomography (CT) scans, especially in cancer screening.

Purpose of the Study:

  • To investigate the relationship between diffuse gastric FDG uptake and gastritis.
  • To compare PET imaging findings with endoscopic results in individuals undergoing cancer screening.

Main Methods:

  • Retrospective analysis of 113 individuals (68 men, 45 women) aged 52 ± 12 years who underwent gastrofiberscopy and PET/CT on the same day.
  • Gastric FDG uptake was visually evaluated and classified as low, moderate, or high.
  • Gastritis severity was classified as mild, moderate, or severe; findings were compared between the upper and lower stomach halves.

Main Results:

  • A significant correlation was found between the degree of gastric FDG uptake and the severity of gastritis (p < 0.0001).
  • High FDG uptake and gastritis were significantly more prevalent in the upper half of the stomach compared to the lower half (p < 0.0001 and p = 0.005, respectively).
  • Significant relationships between FDG uptake and gastritis severity were observed in both upper (p < 0.0001) and lower (p = 0.01) stomach portions.

Conclusions:

  • The study demonstrates a significant association between the severity of gastritis and the degree of diffuse gastric FDG uptake on PET scans.
  • Gastritis is identified as a major contributing factor to diffuse gastric FDG uptake, clarifying a previously unknown cause.
  • These findings have implications for the interpretation of PET/CT imaging, particularly in differentiating inflammatory changes from neoplastic processes in the stomach.