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Gastroesophageal reflux disease in hemodialysis patients

Yoshiaki Kawaguchi1, Tetsuya Mine, Ichiro Kawana

  • 1Department of Gastroenterology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. y711kawa@is.icc.u-tokai.ac.jp

The Tokai Journal of Experimental and Clinical Medicine
|February 15, 2011
PubMed

Insights

The prevalence of gastroesophageal reflux disease (GERD) in chronic renal failure (CRF) patients undergoing hemodialysis (HD) was 24.2%. This study did not identify specific risk factors for increased GERD in this patient population.

Area of Science:

  • Nephrology
  • Gastroenterology

Background:

  • The relationship between gastroesophageal reflux disease (GERD) and chronic renal failure (CRF) is not well-established.
  • Understanding GERD prevalence in hemodialysis (HD) patients is crucial for patient care.

Purpose of the Study:

  • To determine the prevalence of GERD in stable CRF patients undergoing HD.
  • To explore potential pathogenic factors contributing to GERD in this cohort.

Main Methods:

  • A cohort of 418 stable CRF patients on HD was assessed using the QUEST questionnaire for symptomatic GERD.
  • Demographic, clinical, and laboratory data were collected and compared between patients with and without GERD.
  • Gastroendoscopy was not used for GERD diagnosis.

Main Results:

  • The prevalence of GERD among CRF patients on HD was found to be 24.2%.
  • No significant differences were observed in age, sex, BMI, alcohol consumption, smoking, CRF etiology, laboratory values, or medications between GERD and non-GERD groups.

Conclusions:

  • The prevalence of GERD in Japanese CRF patients on HD (24.2%) is higher than the general population prevalence (16.3%).
  • This study did not identify specific risk factors for the increased prevalence of GERD in CRF patients undergoing hemodialysis.
Abstract

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