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5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

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Emerging strategies to preserve renal function.

Hélène Francois¹, Antoine Jacquet, Séverine Beaudreuil

¹Department of Nephrology, Dialysis and Transplantation, Bicêtre Hospital, APHP, Paris, France. helene.francois@bct.aphp.fr

Journal of Nephrology

|February 15, 2011

Summary

Chronic kidney disease (CKD) management needs new strategies beyond current ACE inhibitors or ARBs. Research explores optimizing renin-angiotensin-aldosterone system blockade and novel therapies for better kidney protection.

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Published on: March 27, 2018

Area of Science:

Nephrology
Pharmacology

Background:

Significant advancements in managing chronic kidney disease (CKD) have been made using angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs).
Despite these improvements, CKD progression remains a clinical challenge, necessitating novel therapeutic approaches.

Purpose of the Study:

To review current and emerging strategies for managing chronic kidney disease.
To explore optimal renin-angiotensin-aldosterone system (RAAS) blockade and novel therapeutic agents for nephroprotection.

Main Methods:

Literature review of existing and investigational therapies for CKD.
Discussion of combination therapies, supramaximal dosing, and novel drug classes.
Examination of the nephroprotective roles of adjunctive therapies like statins and vitamin D.

Main Results:

Optimal RAAS blockade remains the cornerstone, but its precise achievement requires further investigation.
Emerging strategies include endothelin receptor antagonists and glitazones.
Other therapies like statins, vitamin D, and erythropoiesis-stimulating agents may offer additional nephroprotective benefits.

Conclusions:

New therapeutic strategies are essential to halt CKD progression.
Further research is needed to optimize RAAS blockade and evaluate novel agents for improved kidney outcomes.