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Updated: Jun 4, 2026
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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
Nuclear receptors in liver disease
Martin Wagner1, Gernot Zollner, Michael Trauner
1Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria.
Hepatology (Baltimore, Md.)
|February 15, 2011
Summary
Nuclear receptors regulate liver functions and diseases. Targeting these receptors offers new therapeutic strategies for various liver conditions, including fatty liver disease and cancer.
Area of Science:
- Hepatology and molecular endocrinology.
Background:
- Nuclear receptors are crucial transcriptional regulators in liver physiology.
- They control vital metabolic processes like lipid metabolism, bile acid homeostasis, and drug disposition.
- Dysregulation of nuclear receptors is implicated in liver pathophysiology, including inflammation, fibrosis, and tumorigenesis.
Purpose of the Study:
- To highlight the role of nuclear receptors in liver function and disease.
- To emphasize their potential as therapeutic targets for hepatic disorders.
Main Methods:
- Review of current literature on nuclear receptor function in the liver.
- Analysis of the link between nuclear receptor dysregulation and liver disease pathogenesis.
Main Results:
- Nuclear receptors govern hepatic lipid metabolism, drug metabolism, and bile acid balance.
- Aberrant nuclear receptor activity contributes to liver diseases such as cholestasis, fatty liver, and cancer.
- Genetic variations in nuclear receptors can influence disease progression.
Conclusions:
- Nuclear receptors are central to liver health and disease.
- Targeting nuclear receptors presents a promising therapeutic avenue for diverse liver diseases, including cholestatic and fatty liver disease, drug-induced liver injury, viral hepatitis, fibrosis, and cancer.
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