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Related Experiment Videos

Decrease of total, glutathione and cysteine SH in non-alcoholic cirrhosis.

C Loguercio1, G Nardi, G Prota

  • 1Istituto di Medicina Generale e Metodologia Clinica, I Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.

The Italian Journal of Gastroenterology
|February 1, 1990
PubMed
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Non-alcoholic liver cirrhosis significantly lowers plasma thiol levels, including glutathione and cysteine. This reduction is independent of nutritional status and may stem from altered transsulfuration pathways.

Area of Science:

  • Biochemistry
  • Hepatology
  • Clinical Nutrition

Background:

  • Non-alcoholic cirrhosis is a progressive liver disease with complex metabolic consequences.
  • Plasma thiols, such as glutathione and cysteine, are crucial antioxidants and play roles in metabolic pathways.
  • Alterations in thiol metabolism may contribute to the pathophysiology of liver disease.

Purpose of the Study:

  • To investigate plasma thiol levels in patients with non-alcoholic cirrhosis.
  • To compare thiol concentrations between cirrhotic patients and healthy controls.
  • To explore potential correlations between thiol levels, nutritional status, and the transsulfuration pathway.

Main Methods:

  • Plasma samples were collected from 42 patients with non-alcoholic cirrhosis and 32 healthy controls.

Related Experiment Videos

  • Total thiols were quantified using Ellman's method.
  • Glutathione and cysteine concentrations were determined by High-Performance Liquid Chromatography (HPLC) with fluorescence detection.

    • Main Results:

    • Patients with non-alcoholic cirrhosis exhibited significantly lower plasma concentrations of total thiols, glutathione, and cysteine compared to healthy subjects.
    • The observed decrease in plasma thiols was not associated with nutritional status or dietary factors.
    • These findings suggest a systemic alteration in thiol metabolism in liver cirrhosis.

    Conclusions:

    • Liver cirrhosis, irrespective of alcohol consumption, leads to a significant reduction in plasma thiol levels.
    • The decrease in plasma thiols is likely secondary to disruptions in the transsulfuration pathway.
    • Further research is warranted to elucidate the precise mechanisms and clinical implications of altered thiol metabolism in cirrhosis.