Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatic fibrosis: cellular aspects.

D M Bissell1

  • 1Liver Core Center, University of California, San Francisco.

The Italian Journal of Gastroenterology
|April 1, 1990
PubMed
Summary
This summary is machine-generated.

Liver

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Poliomyelitis.

California and western medicine·2010
Same author

Chronic liver injury, TGF-beta, and cancer.

Experimental & molecular medicine·2002
Same author

International hepatology.

Hepatology (Baltimore, Md.)·2001
Same author

Transforming growth factor beta and the liver.

Hepatology (Baltimore, Md.)·2001
Same author

Drug-induced liver injury: mechanisms and test systems.

Hepatology (Baltimore, Md.)·2001
Same author

Mechanisms and therapy of hepatic fibrosis: report of the AASLD Single Topic Basic Research Conference.

Hepatology (Baltimore, Md.)·2000
Same journal

Recent Advances on NSAID and NSAID Gastropathy, 1st annual meeting. Ferrara, Italy, 6-7 December 1996. Proceedings.

The Italian journal of gastroenterology·1996
Same journal

Irritable oesophagus syndrome as cause of chronic cough.

The Italian journal of gastroenterology·1996
Same journal

Small bowel tumours in Tuscany.

The Italian journal of gastroenterology·1996
Same journal

Prevalence of hepatitis E in a central Italian town at high endemicity for hepatitis C virus.

The Italian journal of gastroenterology·1996
Same journal

Stimulatory effect of (R) alpha-methylhistamine on duodenal HCO3- secretion in anaesthetized rats.

The Italian journal of gastroenterology·1996
Same journal

Delayed gastric emptying in an infant with Sandifer syndrome.

The Italian journal of gastroenterology·1996
See all related articles

Area of Science:

  • Hepatology and extracellular matrix (ECM) research.

Background:

  • The space of Disse contains ECM proteins, forming a basement membrane crucial for liver cell function.
  • Hepatocyte and lipocyte functions are influenced by their surrounding ECM.
  • Liver inflammation alters the space of Disse's ECM through ectopic protein deposition and normal constituent degradation.

Purpose of the Study:

  • To investigate the role of the extracellular matrix (ECM) in liver function and disease.
  • To understand how alterations in the space of Disse's ECM affect hepatocellular function during inflammation and fibrosis.

Main Methods:

  • Analysis of ECM composition in the space of Disse.
  • Assessment of hepatocellular and lipocyte function in relation to ECM.
  • Evaluation of ECM changes during liver inflammation and fibrosis using clinical and experimental data.

Related Experiment Videos

Main Results:

  • Lipocyte activation is key in producing abnormal ECM and matrix proteinases.
  • Altered ECM in the space of Disse is linked to hepatocellular dysfunction.
  • Inflammation causes ECM changes, including ectopic protein deposition and degradation of normal ECM.

Conclusions:

  • The ECM in the space of Disse is vital for normal liver function.
  • Abnormal ECM, driven by activated lipocytes, contributes to liver fibrosis and hepatocellular dysfunction.
  • Loss of normal ECM support is a significant factor in the deterioration of liver function during disease.